Drug interactions
Glecaprevir / pibrentasvir + Mitoxantrone
Severity: Moderate
Glecaprevir / pibrentasvir and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit the efflux transporter BCRP, and mitoxantrone is a BCRP substrate. Exposure to mitoxantrone may rise, which could increase myelosuppression and cardiotoxicity.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of BCRP-mediated efflux by glecaprevir/pibrentasvir reduces mitoxantrone clearance and increases its absorption and tissue exposure.
What to do
Monitor blood counts closely and watch for signs of cardiotoxicity during coadministration. Consider mitoxantrone dose reduction if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Mitoxantrone?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit the efflux transporter BCRP, and mitoxantrone is a BCRP substrate. Exposure to mitoxantrone may rise, which could increase myelosuppression and cardiotoxicity.
How serious is the interaction between Glecaprevir / pibrentasvir and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and watch for signs of cardiotoxicity during coadministration. Consider mitoxantrone dose reduction if marked myelosuppression occurs.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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