Drug interactions
Glecaprevir / pibrentasvir + Nadolol
Severity: Moderate
Glecaprevir / pibrentasvir and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase exposure to nadolol, a P-gp substrate. This could enhance bradycardia and hypotension.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases nadolol absorption.
What to do
Monitor heart rate and blood pressure during hepatitis C therapy. Reduce the nadolol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Nadolol?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase exposure to nadolol, a P-gp substrate. This could enhance bradycardia and hypotension.
How serious is the interaction between Glecaprevir / pibrentasvir and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during hepatitis C therapy. Reduce the nadolol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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