Drug interactions
Glecaprevir / pibrentasvir + Nicardipine
Severity: Minor
Glecaprevir / pibrentasvir and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and intestinal transporters and may modestly raise nicardipine exposure. Nicardipine's weak CYP3A4 inhibition is unlikely to change glecaprevir or pibrentasvir exposure meaningfully.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glecaprevir and pibrentasvir inhibit P-gp, potentially increasing nicardipine absorption.
What to do
No routine adjustment is needed; monitor blood pressure and heart rate during the hepatitis C treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Nicardipine?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and intestinal transporters and may modestly raise nicardipine exposure. Nicardipine's weak CYP3A4 inhibition is unlikely to change glecaprevir or pibrentasvir exposure meaningfully.
How serious is the interaction between Glecaprevir / pibrentasvir and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and heart rate during the hepatitis C treatment course.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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