Drug interactions
Glecaprevir / pibrentasvir + Paclitaxel
Severity: Moderate
Glecaprevir / pibrentasvir and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and OATP1B1/3, and paclitaxel is a substrate of these transporters. Paclitaxel exposure may increase, with greater risk of myelosuppression and neuropathy.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein and OATP1B1/1B3 transport by glecaprevir/pibrentasvir reduces paclitaxel clearance.
What to do
Monitor blood counts and neurotoxicity during overlap and lower the paclitaxel dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Paclitaxel?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and OATP1B1/3, and paclitaxel is a substrate of these transporters. Paclitaxel exposure may increase, with greater risk of myelosuppression and neuropathy.
How serious is the interaction between Glecaprevir / pibrentasvir and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity during overlap and lower the paclitaxel dose if toxicity occurs.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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