Drug interactions
Glecaprevir / pibrentasvir + Prednisone
Severity: Minor
Glecaprevir / pibrentasvir and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could slightly increase exposure to prednisone, a weak P-gp substrate. Clinically meaningful change is unlikely.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition may modestly raise prednisone absorption.
What to do
No dose adjustment is needed; monitor for typical corticosteroid adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Prednisone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which could slightly increase exposure to prednisone, a weak P-gp substrate. Clinically meaningful change is unlikely.
How serious is the interaction between Glecaprevir / pibrentasvir and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for typical corticosteroid adverse effects.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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