Drug interactions
Glecaprevir / pibrentasvir + Propafenone
Severity: Minor
Glecaprevir / pibrentasvir and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone may inhibit P-glycoprotein and modestly raise glecaprevir and pibrentasvir concentrations. The clinical effect is probably small given the wide tolerability of these agents.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by propafenone increasing absorption of the antivirals.
What to do
No routine adjustment is needed. Monitor for gastrointestinal effects and liver tests as per hepatitis C treatment monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Propafenone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone may inhibit P-glycoprotein and modestly raise glecaprevir and pibrentasvir concentrations. The clinical effect is probably small given the wide tolerability of these agents.
How serious is the interaction between Glecaprevir / pibrentasvir and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for gastrointestinal effects and liver tests as per hepatitis C treatment monitoring.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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