Drug interactions
Glecaprevir / pibrentasvir + Secobarbital
Severity: Major
Glecaprevir / pibrentasvir and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower glecaprevir and pibrentasvir concentrations, risking reduced antiviral efficacy and treatment failure. Strong inducers are not recommended with this regimen.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate induction of CYP3A4 and P-glycoprotein increases clearance of the antivirals.
What to do
Avoid concurrent use and choose a non-inducing sedative. If unavoidable, consult hepatology or infectious diseases and monitor viral response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Secobarbital?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may lower glecaprevir and pibrentasvir concentrations, risking reduced antiviral efficacy and treatment failure. Strong inducers are not recommended with this regimen.
How serious is the interaction between Glecaprevir / pibrentasvir and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-inducing sedative. If unavoidable, consult hepatology or infectious diseases and monitor viral response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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