Drug interactions
Glecaprevir / pibrentasvir + Sitagliptin
Severity: Minor
Glecaprevir / pibrentasvir and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase sitagliptin exposure. Effects are expected to be small. Glucose levels may also shift as hepatitis C is treated and cleared.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition reducing sitagliptin efflux and clearance.
What to do
No dose adjustment is usually necessary. Monitor blood glucose during and after hepatitis C therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Sitagliptin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase sitagliptin exposure. Effects are expected to be small. Glucose levels may also shift as hepatitis C is treated and cleared.
How serious is the interaction between Glecaprevir / pibrentasvir and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually necessary. Monitor blood glucose during and after hepatitis C therapy.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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