Drug interactions
Glecaprevir / pibrentasvir + Verapamil
Severity: Moderate
Glecaprevir / pibrentasvir and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir are P-gp substrates and inhibitors, and verapamil is also a P-gp inhibitor and substrate. Each may increase the other's exposure, with the main clinical concern being greater verapamil effect (hypotension, bradycardia).
What this interaction means in plain words
Glecaprevir / pibrentasvir and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual inhibition of P-glycoprotein efflux, with possible additional CYP3A4 effects.
What to do
Monitor blood pressure, heart rate and ECG during co-administration. Reduce the verapamil dose if excessive effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Verapamil?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both glecaprevir and pibrentasvir are P-gp substrates and inhibitors, and verapamil is also a P-gp inhibitor and substrate. Each may increase the other's exposure, with the main clinical concern being greater verapamil effect (hypotension, bradycardia).
How serious is the interaction between Glecaprevir / pibrentasvir and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG during co-administration. Reduce the verapamil dose if excessive effects occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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