Drug interactions
Glecaprevir / pibrentasvir + Vinblastine
Severity: Moderate
Glecaprevir / pibrentasvir and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase vinblastine exposure. This could heighten myelosuppression and neurotoxicity.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition reduces vinblastine efflux and elimination.
What to do
Monitor blood counts and neurologic and GI toxicity during the short HCV course. Reduce vinblastine if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Vinblastine?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase vinblastine exposure. This could heighten myelosuppression and neurotoxicity.
How serious is the interaction between Glecaprevir / pibrentasvir and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurologic and GI toxicity during the short HCV course. Reduce vinblastine if toxicity appears.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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