Drug interactions
Glibenclamide + Linagliptin-metformin
Severity: Moderate
Glibenclamide and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding linagliptin to a sulfonylurea increases the risk of hypoglycemia. Metformin contributes little hypoglycemia risk on its own but adds to overall glucose lowering.
What this interaction means in plain words
Glibenclamide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Linagliptin-metformin belongs to Endocrine.
Why it happens
Additive glucose lowering: DPP-4 inhibition increases glucose-dependent insulin release on top of sulfonylurea-stimulated insulin secretion.
What to do
Consider reducing the glyburide dose when starting linagliptin-metformin and monitor for hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Glibenclamide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding linagliptin to a sulfonylurea increases the risk of hypoglycemia. Metformin contributes little hypoglycemia risk on its own but adds to overall glucose lowering.
How serious is the interaction between Glibenclamide and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting linagliptin-metformin and monitor for hypoglycemia.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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