Drug interactions
Glibenclamide + Regorafenib
Severity: Moderate
Glibenclamide and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit the efflux transporter BCRP, and glyburide is a substrate of this transporter. Exposure to glyburide could rise and increase the chance of hypoglycemia, although clinical data are limited.
What this interaction means in plain words
Glibenclamide and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Regorafenib belongs to Oncology.
Why it happens
Probable inhibition of BCRP (ABCG2) by regorafenib, reducing efflux of glyburide and increasing its systemic exposure.
What to do
Monitor blood glucose when regorafenib is started and watch for hypoglycemia. Lower the glyburide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Glibenclamide with Regorafenib?
MediHelp rates the interaction as moderate. Glibenclamide and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit the efflux transporter BCRP, and glyburide is a substrate of this transporter. Exposure to glyburide could rise and increase the chance of hypoglycemia, although clinical data are limited.
How serious is the interaction between Glibenclamide and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when regorafenib is started and watch for hypoglycemia. Lower the glyburide dose if glucose falls.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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