Drug interactions
Glibenclamide + Semaglutide
Severity: Moderate
Glibenclamide and Semaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide enhances glucose-dependent insulin secretion, and adding it to glyburide increases the risk of hypoglycemia. Reduced food intake from semaglutide's appetite effects can add to this risk.
What this interaction means in plain words
Glibenclamide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic stimulation of insulin secretion by a GLP-1 receptor agonist and a sulfonylurea.
What to do
Consider lowering the glyburide dose when semaglutide is started. Monitor blood glucose, especially during dose escalation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glibenclamide and Semaglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Semaglutide
Frequently asked questions
Can I take Glibenclamide with Semaglutide?
MediHelp rates the interaction as moderate. Glibenclamide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide enhances glucose-dependent insulin secretion, and adding it to glyburide increases the risk of hypoglycemia. Reduced food intake from semaglutide's appetite effects can add to this risk.
How serious is the interaction between Glibenclamide and Semaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when semaglutide is started. Monitor blood glucose, especially during dose escalation.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
