Drug interactions
Gliclazide + Semaglutide
Severity: Moderate
Gliclazide and Semaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide enhances glucose-dependent insulin secretion and, combined with a sulfonylurea such as gliclazide, increases the risk of hypoglycemia. Reduced appetite and food intake from semaglutide can further contribute.
What this interaction means in plain words
Gliclazide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Additive insulin secretion stimulation from GLP-1 receptor agonism and sulfonylurea action, along with reduced food intake.
What to do
Consider reducing the gliclazide dose when starting or escalating semaglutide and monitor blood glucose. Teach the patient to recognize and treat hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Semaglutide
Frequently asked questions
Can I take Gliclazide with Semaglutide?
MediHelp rates the interaction as moderate. Gliclazide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide enhances glucose-dependent insulin secretion and, combined with a sulfonylurea such as gliclazide, increases the risk of hypoglycemia. Reduced appetite and food intake from semaglutide can further contribute.
How serious is the interaction between Gliclazide and Semaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the gliclazide dose when starting or escalating semaglutide and monitor blood glucose. Teach the patient to recognize and treat hypoglycemia.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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