Drug interactions
Insulin degludec-liraglutide + Semaglutide
Severity: Major
Insulin degludec-liraglutide and Semaglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination already contains the GLP-1 agonist liraglutide, so adding semaglutide duplicates therapy. It increases hypoglycemia and gastrointestinal adverse effects without established added benefit.
What this interaction means in plain words
Insulin degludec-liraglutide and Semaglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-liraglutide belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Duplicate GLP-1 receptor agonism produces additive glucose-lowering and gastrointestinal effects.
What to do
Avoid combining two GLP-1 receptor agonists and choose one regimen. If it occurs, stop one agent and monitor glucose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Semaglutide
- Insulin glargine-lixisenatide + Semaglutide Major
- Chlorpropamide + Semaglutide Moderate
- Gliclazide + Semaglutide Moderate
- Glimepiride-pioglitazone + Semaglutide Moderate
- Glimepiride + Semaglutide Moderate
- Glipizide-metformin + Semaglutide Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Semaglutide?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Semaglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination already contains the GLP-1 agonist liraglutide, so adding semaglutide duplicates therapy. It increases hypoglycemia and gastrointestinal adverse effects without established added benefit.
How serious is the interaction between Insulin degludec-liraglutide and Semaglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two GLP-1 receptor agonists and choose one regimen. If it occurs, stop one agent and monitor glucose.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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