Drug interactions
Glibenclamide + Sitagliptin
Severity: Moderate
Glibenclamide and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sitagliptin raises insulin secretion in a glucose-dependent way, but when added to a sulfonylurea such as glyburide the risk of hypoglycemia increases. Labeling advises considering a lower sulfonylurea dose.
What this interaction means in plain words
Glibenclamide and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Sitagliptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of DPP-4 inhibition and sulfonylurea-stimulated insulin secretion.
What to do
Consider reducing the glyburide dose when sitagliptin is added. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Glibenclamide with Sitagliptin?
MediHelp rates the interaction as moderate. Glibenclamide and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sitagliptin raises insulin secretion in a glucose-dependent way, but when added to a sulfonylurea such as glyburide the risk of hypoglycemia increases. Labeling advises considering a lower sulfonylurea dose.
How serious is the interaction between Glibenclamide and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when sitagliptin is added. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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