Drug interactions
Glibenclamide + Sulphasalazine
Severity: Minor
Glibenclamide and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine may modestly enhance the glucose-lowering effect of sulfonylureas such as glyburide, and hypoglycemia has been described. The effect is inconsistent and generally mild, but can matter in older patients or those with poor intake or renal impairment.
What this interaction means in plain words
Glibenclamide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glibenclamide belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Mechanism is not firmly established; possible displacement from protein binding or additive hypoglycemic effects from the sulfonamide moiety.
What to do
Counsel patients on hypoglycemia symptoms and check blood glucose more often when sulfasalazine is started or stopped. Reduce the glyburide dose if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Sulphasalazine?
MediHelp rates the interaction as minor. Glibenclamide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine may modestly enhance the glucose-lowering effect of sulfonylureas such as glyburide, and hypoglycemia has been described. The effect is inconsistent and generally mild, but can matter in older patients or those with poor intake or renal impairment.
How serious is the interaction between Glibenclamide and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on hypoglycemia symptoms and check blood glucose more often when sulfasalazine is started or stopped. Reduce the glyburide dose if low readings occur.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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