Drug interactions
Glibenclamide + Voclosporin
Severity: Minor
Glibenclamide and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin inhibits OATP1B1, and glyburide is an OATP1B1 substrate, so glyburide exposure may rise. This could increase the risk of hypoglycemia.
What this interaction means in plain words
Glibenclamide and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glibenclamide belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of glyburide by voclosporin.
What to do
Monitor blood glucose and for signs of hypoglycemia when voclosporin is started. Reduce the glyburide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Glibenclamide with Voclosporin?
MediHelp rates the interaction as minor. Glibenclamide and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin inhibits OATP1B1, and glyburide is an OATP1B1 substrate, so glyburide exposure may rise. This could increase the risk of hypoglycemia.
How serious is the interaction between Glibenclamide and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for signs of hypoglycemia when voclosporin is started. Reduce the glyburide dose if needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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