Drug interactions
Gliclazide + Imipramine
Severity: Minor
Gliclazide and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been associated with improved glucose lowering and occasional hypoglycemia in patients taking sulfonylureas. The effect is variable and usually modest, but it can also mask hypoglycemic symptoms.
What this interaction means in plain words
Gliclazide and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Possible additive hypoglycemic effect through altered insulin sensitivity and secretion; the mechanism is not well established.
What to do
Check blood glucose when imipramine is started or stopped. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Gliclazide with Imipramine?
MediHelp rates the interaction as minor. Gliclazide and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been associated with improved glucose lowering and occasional hypoglycemia in patients taking sulfonylureas. The effect is variable and usually modest, but it can also mask hypoglycemic symptoms.
How serious is the interaction between Gliclazide and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose when imipramine is started or stopped. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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