Drug interactions
Gliclazide + Isocarboxazid
Severity: Moderate
Gliclazide and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can lower blood glucose and enhance the effect of sulfonylureas. Hypoglycemia may be prolonged or unexpected.
What this interaction means in plain words
Gliclazide and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition may increase insulin sensitivity and secretion; the exact mechanism is not established.
What to do
Monitor blood glucose when isocarboxazid is started or stopped. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Gliclazide with Isocarboxazid?
MediHelp rates the interaction as moderate. Gliclazide and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can lower blood glucose and enhance the effect of sulfonylureas. Hypoglycemia may be prolonged or unexpected.
How serious is the interaction between Gliclazide and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when isocarboxazid is started or stopped. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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