Drug interactions
Gliclazide + Ivosidenib
Severity: Moderate
Gliclazide and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib may induce CYP2C9, which participates in the metabolism of gliclazide. Lower gliclazide exposure may lead to reduced glycemic control.
What this interaction means in plain words
Gliclazide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9, increasing gliclazide clearance.
What to do
Monitor blood glucose and HbA1c after starting or stopping ivosidenib and increase the gliclazide dose if needed. Consider an alternative antidiabetic agent if control cannot be maintained.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Gliclazide with Ivosidenib?
MediHelp rates the interaction as moderate. Gliclazide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib may induce CYP2C9, which participates in the metabolism of gliclazide. Lower gliclazide exposure may lead to reduced glycemic control.
How serious is the interaction between Gliclazide and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping ivosidenib and increase the gliclazide dose if needed. Consider an alternative antidiabetic agent if control cannot be maintained.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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