Drug interactions
Gliclazide + Ketoconazole
Severity: Moderate
Gliclazide and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can raise sulfonylurea levels and cause hypoglycemia. Although gliclazide is mainly handled by CYP2C9 and CYP2C19, azole antifungals have been reported to enhance its effect.
What this interaction means in plain words
Gliclazide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP enzymes involved in gliclazide metabolism, reducing its clearance.
What to do
Monitor blood glucose closely and reduce the gliclazide dose as needed during ketoconazole therapy. Watch for hypoglycemia after stopping or starting the antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Ketoconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Gliclazide with Ketoconazole?
MediHelp rates the interaction as moderate. Gliclazide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can raise sulfonylurea levels and cause hypoglycemia. Although gliclazide is mainly handled by CYP2C9 and CYP2C19, azole antifungals have been reported to enhance its effect.
How serious is the interaction between Gliclazide and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the gliclazide dose as needed during ketoconazole therapy. Watch for hypoglycemia after stopping or starting the antifungal.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
