Drug interactions
Gliclazide + Meloxicam
Severity: Minor
Gliclazide and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea effects, with occasional hypoglycemia. Meloxicam is metabolized by CYP2C9, which gliclazide also uses, so the effect is plausible but the clinical impact is usually small.
What this interaction means in plain words
Gliclazide and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Meloxicam belongs to Musculoskeletal.
Why it happens
Possible CYP2C9 competition and protein binding displacement; mechanism not clearly established.
What to do
Check blood glucose when starting meloxicam and adjust gliclazide if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Gliclazide with Meloxicam?
MediHelp rates the interaction as minor. Gliclazide and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can potentiate sulfonylurea effects, with occasional hypoglycemia. Meloxicam is metabolized by CYP2C9, which gliclazide also uses, so the effect is plausible but the clinical impact is usually small.
How serious is the interaction between Gliclazide and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose when starting meloxicam and adjust gliclazide if low readings occur.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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