Drug interactions
Gliclazide + Naproxen
Severity: Minor
Gliclazide and Naproxen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may enhance the glucose-lowering effect of sulfonylureas, and isolated hypoglycemia has been described. NSAID-related renal impairment may further raise sulfonylurea exposure.
What this interaction means in plain words
Gliclazide and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Possible protein binding displacement and reduced renal function; mechanism not firmly established.
What to do
Check blood glucose when naproxen is started or stopped and reduce gliclazide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Gliclazide with Naproxen?
MediHelp rates the interaction as minor. Gliclazide and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naproxen may enhance the glucose-lowering effect of sulfonylureas, and isolated hypoglycemia has been described. NSAID-related renal impairment may further raise sulfonylurea exposure.
How serious is the interaction between Gliclazide and Naproxen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose when naproxen is started or stopped and reduce gliclazide if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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