Drug interactions
Gliclazide + Nelfinavir
Severity: Moderate
Gliclazide and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir, like other protease inhibitors, can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of gliclazide. Glycemic control may deteriorate after it is started.
What this interaction means in plain words
Gliclazide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose metabolism.
What to do
Monitor blood glucose and HbA1c after starting nelfinavir and intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Gliclazide with Nelfinavir?
MediHelp rates the interaction as moderate. Gliclazide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir, like other protease inhibitors, can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of gliclazide. Glycemic control may deteriorate after it is started.
How serious is the interaction between Gliclazide and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting nelfinavir and intensify antidiabetic therapy as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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