Drug interactions
Gliclazide + Nortriptyline
Severity: Minor
Gliclazide and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may enhance blood glucose lowering with sulfonylureas, and may blunt awareness of hypoglycemia. Clinically significant events are uncommon.
What this interaction means in plain words
Gliclazide and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Nortriptyline belongs to Central Nervous System.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not well established.
What to do
Monitor blood glucose when nortriptyline is started or stopped. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Gliclazide with Nortriptyline?
MediHelp rates the interaction as minor. Gliclazide and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may enhance blood glucose lowering with sulfonylureas, and may blunt awareness of hypoglycemia. Clinically significant events are uncommon.
How serious is the interaction between Gliclazide and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nortriptyline is started or stopped. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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