Drug interactions
Gliclazide + Ofloxacin
Severity: Moderate
Gliclazide and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause serious hypoglycemia and also hyperglycemia in patients on sulfonylureas. Risk is higher in older patients and those with renal impairment.
What this interaction means in plain words
Gliclazide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Quinolones inhibit pancreatic ATP-sensitive potassium channels, stimulating insulin release in addition to the sulfonylurea effect.
What to do
Monitor blood glucose closely during the antibiotic course and teach the patient to recognize hypoglycemia. Discontinue the quinolone and use an alternative if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Ofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Gliclazide with Ofloxacin?
MediHelp rates the interaction as moderate. Gliclazide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause serious hypoglycemia and also hyperglycemia in patients on sulfonylureas. Risk is higher in older patients and those with renal impairment.
How serious is the interaction between Gliclazide and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and teach the patient to recognize hypoglycemia. Discontinue the quinolone and use an alternative if dysglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
