Drug interactions
Gliclazide + Orlistat
Severity: Minor
Gliclazide and Orlistat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat promotes weight loss and may improve glycemic control, which can lower sulfonylurea requirements. Reduced food intake and improved insulin sensitivity may increase the hypoglycemia risk with gliclazide.
What this interaction means in plain words
Gliclazide and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Orlistat belongs to Miscellaneous.
Why it happens
Additive glucose lowering through reduced fat absorption, weight loss and improved insulin sensitivity.
What to do
Monitor blood glucose as weight falls and reduce the gliclazide dose if hypoglycemia or consistently low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Gliclazide with Orlistat?
MediHelp rates the interaction as minor. Gliclazide and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat promotes weight loss and may improve glycemic control, which can lower sulfonylurea requirements. Reduced food intake and improved insulin sensitivity may increase the hypoglycemia risk with gliclazide.
How serious is the interaction between Gliclazide and Orlistat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose as weight falls and reduce the gliclazide dose if hypoglycemia or consistently low readings occur.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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