Drug interactions
Gliclazide + Phenelzine
Severity: Moderate
Gliclazide and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as phenelzine can lower blood glucose and enhance the hypoglycemic effect of sulfonylureas, sometimes causing significant hypoglycemia.
What this interaction means in plain words
Gliclazide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin secretion and sensitivity, adding to the sulfonylurea effect; the mechanism is not fully established.
What to do
Monitor blood glucose closely when starting phenelzine and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Gliclazide with Phenelzine?
MediHelp rates the interaction as moderate. Gliclazide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as phenelzine can lower blood glucose and enhance the hypoglycemic effect of sulfonylureas, sometimes causing significant hypoglycemia.
How serious is the interaction between Gliclazide and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting phenelzine and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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