Drug interactions
Gliclazide + Prednisolone
Severity: Moderate
Gliclazide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone increases blood glucose and can reduce the effectiveness of gliclazide. Hyperglycemia may be marked with high doses or prolonged therapy, and hypoglycemia can occur as the dose is tapered.
What this interaction means in plain words
Gliclazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced gluconeogenesis and insulin resistance.
What to do
Monitor blood glucose frequently during steroid therapy and increase gliclazide or add insulin if needed. Reduce the antidiabetic dose as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Gliclazide with Prednisolone?
MediHelp rates the interaction as moderate. Gliclazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone increases blood glucose and can reduce the effectiveness of gliclazide. Hyperglycemia may be marked with high doses or prolonged therapy, and hypoglycemia can occur as the dose is tapered.
How serious is the interaction between Gliclazide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during steroid therapy and increase gliclazide or add insulin if needed. Reduce the antidiabetic dose as the steroid is tapered.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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