Drug interactions
Gliclazide + Rasagiline
Severity: Minor
Gliclazide and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been associated with enhanced glucose-lowering in patients on antidiabetic drugs. Rasagiline is selective for MAO-B at recommended doses, so the effect is likely small, but hypoglycemia is possible with a sulfonylurea such as gliclazide.
What this interaction means in plain words
Gliclazide and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gliclazide belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may alter glucose homeostasis and add to the effect of the sulfonylurea.
What to do
Monitor blood glucose when rasagiline is started or stopped in a patient taking gliclazide. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Gliclazide with Rasagiline?
MediHelp rates the interaction as minor. Gliclazide and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors have been associated with enhanced glucose-lowering in patients on antidiabetic drugs. Rasagiline is selective for MAO-B at recommended doses, so the effect is likely small, but hypoglycemia is possible with a sulfonylurea such as gliclazide.
How serious is the interaction between Gliclazide and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rasagiline is started or stopped in a patient taking gliclazide. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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