Drug interactions
Gliclazide + Selegiline
Severity: Moderate
Gliclazide and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the glucose-lowering effect of sulfonylureas, raising the risk of hypoglycemia. Selegiline is MAO-B selective at low oral doses so the effect is probably modest.
What this interaction means in plain words
Gliclazide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may enhance insulin secretion or alter glucose metabolism.
What to do
Monitor blood glucose closely when selegiline is added, and lower the gliclazide dose if hypoglycemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gliclazide and Selegiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Gliclazide with Selegiline?
MediHelp rates the interaction as moderate. Gliclazide and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may potentiate the glucose-lowering effect of sulfonylureas, raising the risk of hypoglycemia. Selegiline is MAO-B selective at low oral doses so the effect is probably modest.
How serious is the interaction between Gliclazide and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when selegiline is added, and lower the gliclazide dose if hypoglycemia appears.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
