Drug interactions
Gliclazide + Trandolapril
Severity: Moderate
Gliclazide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been linked to increased hypoglycemia in patients taking sulfonylureas. The risk is greatest early in therapy and in patients with renal impairment.
What this interaction means in plain words
Gliclazide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
ACE inhibition increases insulin sensitivity, possibly via raised bradykinin, adding to the sulfonylurea effect.
What to do
Monitor glucose when trandolapril is started or the dose is increased, and reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Gliclazide with Trandolapril?
MediHelp rates the interaction as moderate. Gliclazide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been linked to increased hypoglycemia in patients taking sulfonylureas. The risk is greatest early in therapy and in patients with renal impairment.
How serious is the interaction between Gliclazide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when trandolapril is started or the dose is increased, and reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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