Drug interactions
Glimepiride + Indapamide
Severity: Minor
Glimepiride and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide may raise blood glucose and weaken the effect of glimepiride. Glycemic control may deteriorate after the diuretic is started.
What this interaction means in plain words
Glimepiride and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Diuretic-related hypokalemia and reduced insulin secretion and sensitivity oppose sulfonylurea action.
What to do
Monitor blood glucose after starting indapamide and adjust glimepiride dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glimepiride and Indapamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Indapamide?
MediHelp rates the interaction as minor. Glimepiride and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide may raise blood glucose and weaken the effect of glimepiride. Glycemic control may deteriorate after the diuretic is started.
How serious is the interaction between Glimepiride and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting indapamide and adjust glimepiride dose if needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
