Drug interactions
Glimepiride + Indinavir
Severity: Moderate
Glimepiride and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir has been associated with insulin resistance and hyperglycemia, which can weaken the glucose-lowering effect of glimepiride. The magnitude varies between patients.
What this interaction means in plain words
Glimepiride and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir reduces insulin-mediated glucose uptake, causing insulin resistance that opposes the sulfonylurea effect.
What to do
Monitor blood glucose and HbA1c after starting indinavir and titrate glimepiride or add other agents as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Indinavir?
MediHelp rates the interaction as moderate. Glimepiride and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir has been associated with insulin resistance and hyperglycemia, which can weaken the glucose-lowering effect of glimepiride. The magnitude varies between patients.
How serious is the interaction between Glimepiride and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting indinavir and titrate glimepiride or add other agents as needed.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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