Drug interactions
Glimepiride + Insulin aspart-insulin aspart protamine
Severity: Moderate
Glimepiride and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glimepiride with insulin gives additive glucose lowering and increases hypoglycemia risk. Dose reductions may be needed.
What this interaction means in plain words
Glimepiride and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor glucose closely and reduce the dose of either agent if hypoglycemia occurs. Teach hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Glimepiride and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glimepiride with insulin gives additive glucose lowering and increases hypoglycemia risk. Dose reductions may be needed.
How serious is the interaction between Glimepiride and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the dose of either agent if hypoglycemia occurs. Teach hypoglycemia recognition and treatment.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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