Drug interactions
Glimepiride + Insulin detemir
Severity: Moderate
Glimepiride and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glimepiride with insulin gives additive glucose lowering and increases the risk of hypoglycemia, which can be severe.
What this interaction means in plain words
Glimepiride and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Insulin detemir belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor glucose closely and reduce the sulfonylurea or insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Insulin detemir?
MediHelp rates the interaction as moderate. Glimepiride and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glimepiride with insulin gives additive glucose lowering and increases the risk of hypoglycemia, which can be severe.
How serious is the interaction between Glimepiride and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the sulfonylurea or insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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