Drug interactions
Glimepiride + Insulin lispro
Severity: Moderate
Glimepiride and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with a sulfonylurea increases the risk of hypoglycemia, which can be severe, particularly in older patients or those with renal impairment or irregular meals.
What this interaction means in plain words
Glimepiride and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor glucose frequently and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Insulin lispro?
MediHelp rates the interaction as moderate. Glimepiride and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with a sulfonylurea increases the risk of hypoglycemia, which can be severe, particularly in older patients or those with renal impairment or irregular meals.
How serious is the interaction between Glimepiride and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia recognition and treatment.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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