Drug interactions
Glimepiride + Isoniazid
Severity: Minor
Glimepiride and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glycemic control in diabetic patients, which may reduce the effect of sulfonylureas such as glimepiride. Evidence is limited and the effect is variable.
What this interaction means in plain words
Glimepiride and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Mechanism not established; isoniazid may impair glucose control.
What to do
Monitor blood glucose when isoniazid is started or stopped and adjust the glimepiride dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Isoniazid?
MediHelp rates the interaction as minor. Glimepiride and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can impair glycemic control in diabetic patients, which may reduce the effect of sulfonylureas such as glimepiride. Evidence is limited and the effect is variable.
How serious is the interaction between Glimepiride and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when isoniazid is started or stopped and adjust the glimepiride dose if needed.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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