Drug interactions
Glimepiride + Ketorolac
Severity: Moderate
Glimepiride and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Ketorolac may also impair renal function, which can prolong sulfonylurea effects.
What this interaction means in plain words
Glimepiride and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal function; the mechanism is not firmly established.
What to do
Monitor blood glucose when ketorolac is started or stopped and counsel the patient about hypoglycemia symptoms. Adjust the glimepiride dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Ketorolac?
MediHelp rates the interaction as moderate. Glimepiride and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Ketorolac may also impair renal function, which can prolong sulfonylurea effects.
How serious is the interaction between Glimepiride and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ketorolac is started or stopped and counsel the patient about hypoglycemia symptoms. Adjust the glimepiride dose if glucose falls.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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