Drug interactions
Glimepiride + Lumacaftor / ivacaftor
Severity: Moderate
Glimepiride and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an inducer of metabolizing enzymes and may reduce glimepiride exposure through CYP2C9 induction. This can cause reduced glycemic control in diabetic patients.
What this interaction means in plain words
Glimepiride and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9, increasing glimepiride clearance.
What to do
Monitor blood glucose closely when starting lumacaftor/ivacaftor and titrate glimepiride upward as needed. Reassess the dose if the CFTR modulator is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Glimepiride and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an inducer of metabolizing enzymes and may reduce glimepiride exposure through CYP2C9 induction. This can cause reduced glycemic control in diabetic patients.
How serious is the interaction between Glimepiride and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting lumacaftor/ivacaftor and titrate glimepiride upward as needed. Reassess the dose if the CFTR modulator is stopped.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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