Drug interactions
Glimepiride + Metronidazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Metronidazole may increase glimepiride exposure and enhance hypoglycemic effects.
Mechanism of action
Pharmacokinetic: Metronidazole inhibits CYP2C9, reducing glimepiride metabolism; pharmacodynamic enhancement of hypoglycemia may result.
Clinical management
Monitor blood glucose closely during metronidazole therapy and for several days after completion; consider temporary glimepiride dose reduction; counsel on hypoglycemia signs and ensure access to rapid-acting carbohydrates.
Drug reference
References
- Glimepiride: Drug Interactions — Lexicomp
- Metronidazole: Drug Interactions — Lexicomp
- Amaryl (glimepiride) Prescribing Information — FDA Label
Frequently asked questions
Can I take Glimepiride with Metronidazole?
The interaction is rated: Moderate. Metronidazole may increase glimepiride exposure and enhance hypoglycemic effects.
How serious is the interaction between Glimepiride and Metronidazole?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Glimepiride and Metronidazole managed?
Monitor blood glucose closely during metronidazole therapy and for several days after completion; consider temporary glimepiride dose reduction; counsel on hypoglycemia signs and ensure access to rapid-acting carbohydrates.
Why do Glimepiride and Metronidazole interact?
Pharmacokinetic: Metronidazole inhibits CYP2C9, reducing glimepiride metabolism; pharmacodynamic enhancement of hypoglycemia may result.
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