Drug interactions
Glimepiride + Miconazole vaginal
Severity: Moderate
Glimepiride and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP2C9 inhibitor and systemic absorption from vaginal products can be enough to raise exposure to sulfonylureas, with reported hypoglycemia for oral miconazole. The risk with vaginal use is lower but is plausible, especially with repeated or prolonged use.
What this interaction means in plain words
Glimepiride and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9-mediated metabolism of glimepiride by absorbed miconazole.
What to do
Counsel patients on hypoglycemia symptoms and check blood glucose more often during the course of miconazole; reduce the glimepiride dose if low readings occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Miconazole vaginal?
MediHelp rates the interaction as moderate. Glimepiride and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole is a CYP2C9 inhibitor and systemic absorption from vaginal products can be enough to raise exposure to sulfonylureas, with reported hypoglycemia for oral miconazole. The risk with vaginal use is lower but is plausible, especially with repeated or prolonged use.
How serious is the interaction between Glimepiride and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on hypoglycemia symptoms and check blood glucose more often during the course of miconazole; reduce the glimepiride dose if low readings occur.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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