Drug interactions
Glimepiride + Mipomersen
Severity: Moderate
Glimepiride and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity with raised transaminases and hepatic fat accumulation. Because glimepiride is hepatically cleared, liver injury could alter its handling, and the combination adds to overall hepatic monitoring burden.
What this interaction means in plain words
Glimepiride and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential for hepatic enzyme elevation; not a defined pharmacokinetic interaction.
What to do
Monitor liver enzymes per mipomersen labeling and watch for hypoglycemia if hepatic function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Mipomersen?
MediHelp rates the interaction as moderate. Glimepiride and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause hepatotoxicity with raised transaminases and hepatic fat accumulation. Because glimepiride is hepatically cleared, liver injury could alter its handling, and the combination adds to overall hepatic monitoring burden.
How serious is the interaction between Glimepiride and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes per mipomersen labeling and watch for hypoglycemia if hepatic function declines.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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