Drug interactions
Glimepiride + Oxymetholone
Severity: Moderate
Glimepiride and Oxymetholone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone is an anabolic steroid that can lower blood glucose by improving insulin sensitivity. Together with glimepiride it may increase the risk of hypoglycemia.
What this interaction means in plain words
Glimepiride and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering through enhanced insulin sensitivity alongside sulfonylurea-driven insulin secretion.
What to do
Check blood glucose more often when starting or stopping oxymetholone. Lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Oxymetholone?
MediHelp rates the interaction as moderate. Glimepiride and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxymetholone is an anabolic steroid that can lower blood glucose by improving insulin sensitivity. Together with glimepiride it may increase the risk of hypoglycemia.
How serious is the interaction between Glimepiride and Oxymetholone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when starting or stopping oxymetholone. Lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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