Drug interactions
Glimepiride + Parecoxib
Severity: Minor
Glimepiride and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs including COX-2 inhibitors can occasionally potentiate sulfonylurea-induced hypoglycemia. Renal effects of the NSAID may further affect glycemic control.
What this interaction means in plain words
Glimepiride and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not firmly established; possible CYP2C9 competition and renal prostaglandin effects.
What to do
Monitor blood glucose during short-term parecoxib use and reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Parecoxib?
MediHelp rates the interaction as minor. Glimepiride and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs including COX-2 inhibitors can occasionally potentiate sulfonylurea-induced hypoglycemia. Renal effects of the NSAID may further affect glycemic control.
How serious is the interaction between Glimepiride and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during short-term parecoxib use and reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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