Drug interactions
Glimepiride + Quinapril
Severity: Moderate
Glimepiride and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and potentiate the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is most noticeable early after starting the ACE inhibitor.
What this interaction means in plain words
Glimepiride and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Improved insulin sensitivity and possibly increased bradykinin activity add to the sulfonylurea effect.
What to do
Monitor blood glucose when starting quinapril and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Quinapril?
MediHelp rates the interaction as moderate. Glimepiride and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and potentiate the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is most noticeable early after starting the ACE inhibitor.
How serious is the interaction between Glimepiride and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting quinapril and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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