Drug interactions
Glimepiride + Sage
Severity: Minor
Glimepiride and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage preparations have shown glucose-lowering activity in some small studies. Taken with glimepiride they could add to the effect and lead to hypoglycemia, especially with concentrated extracts or teas.
What this interaction means in plain words
Glimepiride and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect of sage constituents; mechanism not well established.
What to do
Monitor blood glucose if the patient uses sage medicinally in significant amounts. Reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Sage?
MediHelp rates the interaction as minor. Glimepiride and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage preparations have shown glucose-lowering activity in some small studies. Taken with glimepiride they could add to the effect and lead to hypoglycemia, especially with concentrated extracts or teas.
How serious is the interaction between Glimepiride and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if the patient uses sage medicinally in significant amounts. Reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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