Drug interactions
Glimepiride + Salsalate
Severity: Moderate
Glimepiride and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylate and can lower blood glucose by itself, which may add to the effect of glimepiride and cause hypoglycemia.
What this interaction means in plain words
Glimepiride and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypoglycemic effect of salicylate, with possible protein-binding displacement.
What to do
Monitor blood glucose when salsalate is started or its dose changed and lower the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Salsalate?
MediHelp rates the interaction as moderate. Glimepiride and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylate and can lower blood glucose by itself, which may add to the effect of glimepiride and cause hypoglycemia.
How serious is the interaction between Glimepiride and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when salsalate is started or its dose changed and lower the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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