Drug interactions
Glimepiride + Sulfamethoxypyridazine
Severity: Moderate
Glimepiride and Sulfamethoxypyridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can enhance the glucose-lowering effect of sulfonylureas and have been associated with episodes of hypoglycemia. The risk is greater in elderly patients and those with renal impairment.
What this interaction means in plain words
Glimepiride and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible displacement from plasma protein binding and inhibition of CYP2C9-mediated sulfonylurea metabolism, with additive hypoglycemic effects.
What to do
Monitor blood glucose closely when starting or stopping the sulfonamide and counsel the patient on hypoglycemia symptoms. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Sulfamethoxypyridazine?
MediHelp rates the interaction as moderate. Glimepiride and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibacterials can enhance the glucose-lowering effect of sulfonylureas and have been associated with episodes of hypoglycemia. The risk is greater in elderly patients and those with renal impairment.
How serious is the interaction between Glimepiride and Sulfamethoxypyridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping the sulfonamide and counsel the patient on hypoglycemia symptoms. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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